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pfus restored normal nonlinear dynamics  (Nonlinear Dynamics)
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Nonlinear Dynamics pfus restored normal nonlinear dynamics
Integrated mechanistic framework of <t>pFUS-mediated</t> seizure suppression. pFUS modulates neural activity through dual cellular pathways: the preferential activation of GABAergic interneurons and astrocytic mechano-transduction, leading to disrupted hypersynchrony <t>and</t> <t>restored</t> excitation–inhibition balance. These cellular effects propagate to network-level modulation, characterized by desynchronization and increased signal complexity. Ultimately, these processes drive system-level outcomes, including acute seizure reduction and long-term benefits mediated by neuroprotection.
Pfus Restored Normal Nonlinear Dynamics, supplied by Nonlinear Dynamics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Integrated mechanistic framework of pFUS-mediated seizure suppression. pFUS modulates neural activity through dual cellular pathways: the preferential activation of GABAergic interneurons and astrocytic mechano-transduction, leading to disrupted hypersynchrony and restored excitation–inhibition balance. These cellular effects propagate to network-level modulation, characterized by desynchronization and increased signal complexity. Ultimately, these processes drive system-level outcomes, including acute seizure reduction and long-term benefits mediated by neuroprotection.

Journal: Neurotherapeutics

Article Title: Pulsed focused ultrasound for seizure suppression: Mechanisms, models, and clinical translation

doi: 10.1016/j.neurot.2026.e00920

Figure Lengend Snippet: Integrated mechanistic framework of pFUS-mediated seizure suppression. pFUS modulates neural activity through dual cellular pathways: the preferential activation of GABAergic interneurons and astrocytic mechano-transduction, leading to disrupted hypersynchrony and restored excitation–inhibition balance. These cellular effects propagate to network-level modulation, characterized by desynchronization and increased signal complexity. Ultimately, these processes drive system-level outcomes, including acute seizure reduction and long-term benefits mediated by neuroprotection.

Article Snippet: 3 , KA chronic epilepsy C57BL/6 mice (N = 14)/KA injection at CA3 region , MI: 0.37, I SPTA : 1.13 W/cm 2 (with skull attenuation), DC: 50 %, SD: 30 s, one session , pFUS-seizure suppression correlated with restoration of neural signal complexity: Approximate entropy increased (delta and theta band); largest lyapunov exponent increased. pFUS restored normal nonlinear dynamics , [ ] .

Techniques: Activity Assay, Activation Assay, Transduction, Inhibition